Tetanus neurotoxin: conformational plasticity as an adaptive strategy
نویسندگان
چکیده
منابع مشابه
Metal substitution of tetanus neurotoxin.
Tetanus neurotoxin was depleted of its catalytic Zn2+ ion, and the apotoxin was reconstituted with different transition metal ions. The Mn2+- and Co2+-tetanus neurotoxins are highly active in the proteolysis of vesicle-associated membrane protein/synaptobrevin, the natural substrate of this toxin, whereas Cu2+ and Fe2+ minimally supported proteolytic activity. The visible absorbance spectrum of...
متن کاملMorphological plasticity in the reef zoanthid Palythoa caribaeorum as an adaptive strategy
1) Posgraduação em Biologia Animal, Universidade Federal de Pernambuco, Rua Prof. Moraes Rego 1235, Cidade Universitária, 50670-420 Recife, Pernambuco, Brazil 2) Departamento de Biologia, Área Ecologia, Universidade Federal Rural de Pernambuco, Rua Dom Manoel de Medeiros, s/n, Dois Irmãos, 52171-900 Recife, Pernambuco, Brazil 3) Centro Acadêmico de Vitória, Universidade Federal de Pernambuco, R...
متن کاملPlasticity in Meristem Allocation as an Adaptive Strategy of a Desert Shrub under Contrasting Environments
The pattern of resource allocation to reproduction vs. vegetative growth is a core component of a plant's life-history strategy. Plants can modify their biomass allocation patterns to adapt to contrasting environments. Meristems can have alternative fates to commit to vegetative growth, reproduction, or remaining inactive (dormant or senescent/dead). However, knowledge about whether meristem fa...
متن کاملPlasticity in coloration as an antipredator strategy among zooplankton
We show that marine zooplankton change their level of coloration both with depth and time of the day. The carnivorous copepod Pareuchaeta norvegica caught near the bottom in 200–400-m deep-water columns were darker than specimens caught higher in the water column. A diel rhythm in coloration occurred even at several hundred meters’ depth, with individuals caught during night time being more pig...
متن کاملSubstrate recognition of VAMP-2 by botulinum neurotoxin B and tetanus neurotoxin.
Botulinum neurotoxin (BoNT; serotypes A-G) and tetanus neurotoxin elicit flaccid and spastic paralysis, respectively. These neurotoxins are zinc proteases that cleave SNARE proteins to inhibit synaptic vesicle fusion to the plasma membrane. Although BoNT/B and tetanus neurotoxin (TeNT) cleave VAMP-2 at the same scissile bond, their mechanism(s) of VAMP-2 recognition is not clear. Mapping experi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: EMBO reports
سال: 2017
ISSN: 1469-221X,1469-3178
DOI: 10.15252/embr.201744500